Deterioration in Lung Function after General Anaesthesia in Patients with Cystic Fibrosis

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Abstract
Forty-eight h after esophagoscopy and injection sclerotherapy of esophageal varices under general anesthesia, 11 studies of 6 children with cystic fibrosis and portal hypertension showed a significant deterioration in 4 tests of lung function. The largest falls were seen in forced expiratory volume in 1 s [FEV1s] (P < 0.01) and forced expiratory flow between 25 and 75% of vital capacity (P < 0.02). In 14 studies of 10 children with portal hypertension from other causes, a significant fall occurred only in peak expiratory flow rate (P < 0.01). The slight falls in FEV1s and forced expiratory flow between 25 and 75% of vital capacity were significantly smaller than those observed in the patients with cystic fibrosis (P < 0.05; P < 0.01).