VIRUS-INDUCED DIABETES AND THE IMMUNE SYSTEM-2 - EVIDENCE FOR AN IMMUNE PATHOGENESIS OF THE ACUTE PHASE OF DIABETES

  • 1 January 1979
    • journal article
    • letter
    • Vol. 31  (1) , 1-2
Abstract
The infection of normal DBA2 and BALB/C nu/+ mice with 2 .times. 102,6 TCID50 [median tissue culture infectious dose] of the M variant of the EMC [encephalomyocarditis virus] virus induced pathological mean glucose values of 426 .+-. 99 mg/100 ml in DBA2 mice and 292 .+-. 130 mg/100 ml in BALB/C nu/+ mice on day 5 following infection. As diabetic animals died afterwards, mean glucose values decreased in the surviving animals on day 7 and 14. The infected immunodeficient BALB/C nu/nu mice with thymus aplasia did not show abnormal mean glucose values or higher standard deviation of the means (114 .+-. 37 mg/100 ml) when compared to uninfected controls (117 .+-. 23 mg/100 ml). A complete thymus-dependent immune system seems necessary for the development of the acute stage of virus-induced diabetes in the mouse.

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