Studies on Peptides. XXIII. Total Synthesis of Monkey β-Melanocyte-stimulating Hormone
- 1 January 1969
- journal article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 17 (6) , 1237-1245
- https://doi.org/10.1248/cpb.17.1237
Abstract
Total synthesis of monkey β-melanocyte-stimulating hormone was described. The synthesis involved in the coupling reaction of Na-t-butoxycarbonyl-β-t-butylaspartyl-γ-t-butylglutamylglycine with prolyltyrosylarginylmethionylglutamylhistidylphenylalanylarginyltryptophylglycylserylprolylprolyl-Nε-formyllysylaspartic acid by the N-hydroxysuccinimide ester method and subsequent removal of all of the protecting groups from the product, i. e., t-butyl and t-butoxycarbonyl groups by trifluoroacetic acid and the formyl group by hydrazine acetate. Synthetic monkey β-MSH exhibited 6×109 and 2.5×1010MSH U/g.Keywords
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