Pancreatic cancer: the potential clinical relevance of alterations in growth factors and their receptors
- 1 January 1996
- journal article
- review article
- Published by Springer Nature in Journal of Molecular Medicine
- Vol. 74 (1) , 35-42
- https://doi.org/10.1007/bf00202070
Abstract
Molecular alterations play a key role in the pathogenesis of gastrointestinal cancers. In the present paper we describe relevant molecular alterations in human pancreatic adenocarcinomas. Overexpression of growth factor receptors (EGF receptor, c-erbB2, c-erbB3, TGFβ receptor I–III), growth factors (EGF, TGFα, TGFβ-1-3, aFGF, bFGF), adhesion molecules (ICAM-1, ELAM-1) and gene mutations (p53, K-ras, DCC, APC) are present in a significant number of these tumors. These changes stimulate tumor growth and enhance the metastatic behavior of pancreatic cancer cells and thereby may contribute to shorter postoperative survival following tumor resection.Keywords
This publication has 96 references indexed in Scilit:
- Low-Dose Octreotide Treatment Is Not Effective in Patients with Advanced Pancreatic CancerPancreas, 1993
- The type 1 (EGFR-related) family of growth factor receptors and their ligandsProgress in Growth Factor Research, 1992
- Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor alpha.Journal of Clinical Investigation, 1992
- A randomized controlled trial of adjuvant immunotherapy (murine monoclonal antibody 494/32) in resectable pancreatic cancerCancer, 1991
- The p53 tumour suppressor geneNature, 1991
- Loss of growth inhibitory activity of TGF-β toward normal human mammary epithelial cells grown within collagen gel matrixBiochemical and Biophysical Research Communications, 1990
- Activation of c‐Ki‐ras not detectable in adenomas or adenocarcinomas arising in rat pancreasMolecular Carcinogenesis, 1990
- Mutations in the p53 gene occur in diverse human tumour typesNature, 1989
- The fibroblast growth factor family: Structural and biological propertiesProgress in Growth Factor Research, 1989
- Molecular and biological characterization of fibroblast growth factor, an angiogenic factor which also controls the proliferation and differentiation of mesoderm and neuroectoderm derived cellsCell Differentiation, 1986