TESTICULAR REGRESSION SYNDROME

  • 1 January 1979
    • journal article
    • research article
    • Vol. 53  (1) , 44-49
Abstract
The testicular regression syndrome was reported as being representative of a clinical range of XY agonadal persons. A patient with aberrant fetal sexual development is described. Of particular interest is that all of the tissues examined, the rudimentary uterine horn and the 2 fallopian tubes, displayed an XY chromosome complement. Correlation was made between the known temporal events of embryogenesis of the testes and the apparent time of regression of the testes. The insult to testicular development, with subsequent testicular regression occurred 48-60 days after fertilization. In certain XY persons the testes apparently are irreparably damaged at a critical stage in fetal development. This critical stage is represented by a range of abnormalities of genital development. Possible causes and simplified nomenclature for such gonadal damage are presented.