Macrolide antibiotics M-4365 produced by Micromonospora. III. In vitro antimicrobial activity of antibiotic M-4365G2(de-epoxy rosamicin).

31 December 1977

journal article
research article
Published by Japan Antibiotics Research Association in The Journal of Antibiotics

Vol. 31 (5) , 433-440
https://doi.org/10.7164/antibiotics.31.433

Abstract

Antibiotic M-4365G2 (de-epoxy rosamicin) produced by M. capillata MCRL 0940 is a new basic 16-membered macrolide antibiotic with activity equal to or superior to erythromycin and josamycin against gram-positive bacteria. Of interest are the high degree of activity against gram-negative bacilli and myocplasmas, and striking of inhibitory effects against indole-producing Proteus spp. Bactericidal activity of M-4365G2 is also noted.