THE SECRETION OF ALKALINE PHOSPHATASE BY THE DOG'S INTESTINE

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Abstract
The phosphatase activity of duodenal, jejunal and ileal chyme obtained from enterostomized dogs was detd. after the following test meals: milk, meat, olive and corn oils, casein, and sucrose. The greatest activity was found after the protein and fat meals, the values, in Bodansky units per 100 cci, being 2170, 4404 and 23989 for protein and 2252, 8671 and 20806 for fat, at the duodenal, jejunal and ileal levels respectively. The phosphatase activity of the intestinal contents increased as they passed caudalwards, ileal chyme having an activity 7 to 10 times greater than that of the duodenum. The secretions of isolated intestinal loops of dogs with acute or chronic Thiry-Vella fistulae contained large quantities of phosphatase. The order of activity of the secretions from the various intestinal segments was: duodenum > jejunum > ileum > colon. The increased activity of ileal chyme cited above is due to a cone, of the intestinal contents and not to a greater secretion by the lower gut. Phosphatase is considered to be a true secretion of the intestinal tract, especially of the duodenum and jejunum.

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