A Stochastic Two‐Stage Model for Cancer Risk Assessment. I. The Hazard Function and the Probability of Tumor
- 1 September 1988
- journal article
- Published by Wiley in Risk Analysis
- Vol. 8 (3) , 383-392
- https://doi.org/10.1111/j.1539-6924.1988.tb00502.x
Abstract
We present a mathematical treatment of a two-mutation model for carcinogenesis with time-dependent parameters. This model has previously been shown to be consistent with epidemiologic and experimental data. An approximate hazard function used in previous papers is critically evaluated.Keywords
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