HLA-B alleles of the Navajo: no evidence for rapid evolution in the Nadene
- 1 February 1996
- journal article
- Published by Wiley in Tissue Antigens
- Vol. 47 (2) , 143-146
- https://doi.org/10.1111/j.1399-0039.1996.tb02528.x
Abstract
New HLA-B locus alleles have been found in South American Amerindian populations but were largely absent in North American Amerindian tribes also descended from this first Paleo-Indian migration. We have now extended these studies to the Navajo, descendants of the second Nadene migration. No new functional alleles were found at the B locus of this tribe. This limited study supports the notion that while new B locus variants are common in South American Amerindians, it is more difficult to find new B locus alleles in North American native peoples. Whether this dichotomy is due to differences in pathogen environment and/or population structures between North and South America remains a subject of speculation.Keywords
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