5‐HT6 receptor antagonist SB‐271046 enhances extracellular levels of monoamines in the rat medial prefrontal cortex
- 7 November 2003
- Vol. 51 (2) , 158-164
- https://doi.org/10.1002/syn.10288
Abstract
The present study investigated the neurochemical effects of the selective 5‐HT6 receptor antagonist SB‐271046 in the rat medial prefrontal cortex (mPFC). The effect of SB‐271046 on extracellular levels of dopamine (DA), norepinephrine (NE), and serotonin (5‐HT) in the mPFC was examined using in vivo microdialysis in the freely moving rat. SB‐271046 (10 mg/kg, p.o.) produced a significant increase in extracellular levels of both DA and NE without altering 5‐HT neurotransmission. These results further support the rationale for the use of 5‐HT6 receptor antagonists in the treatment of cognitive dysfunction associated with psychiatric diseases. Synapse 51:158–164, 2004.Keywords
This publication has 41 references indexed in Scilit:
- Characterization of SB‐271046: A potent, selective and orally active 5‐HT6 receptor antagonistBritish Journal of Pharmacology, 2000
- 5-ht6 Receptors as Emerging Targets for Drug DiscoveryAnnual Review of Pharmacology and Toxicology, 2000
- Antibodies and Antisense Oligonucleotide for Probing the Distribution and Putative Functions of Central 5-HT6 ReceptorsNeuropsychopharmacology, 1999
- Stimulation of Type 1 and Type 8 Ca2+/Calmodulin-sensitive Adenylyl Cyclases by the Gs-coupled 5-Hydroxytryptamine Subtype 5-HT7AReceptorPublished by Elsevier ,1998
- Estimation of in-vivo neurotransmitter release by brain microdialysisBehavioural Pharmacology, 1996
- Serotonin receptors: Subtypes, functional responses and therapeutic relevancePharmacology & Therapeutics, 1995
- Delayed-response deficit induced by local injection of the α2-adrenergic antagonist yohimbine into the dorsolateral prefrontal cortex in young adult monkeysBehavioral and Neural Biology, 1994
- A Novel Rat Serotonin (5-HT6) Receptor: Molecular Cloning, Localization and Stimulation of cAMP AccumulationBiochemical and Biophysical Research Communications, 1993
- Effects of medetomidine, an α-2 adrenoceptor agonist, and atipamezole, an α-2 antagonist, on spatial memory performance in adult and aged ratsBehavioral and Neural Biology, 1992
- Functions of the frontal cortex of the rat: A comparative reviewBrain Research Reviews, 1984