Cisplatin and carboplatin-mediated activation of murine peritoneal macrophages in vitro
- 1 April 1995
- journal article
- research article
- Published by Wolters Kluwer Health in Anti-Cancer Drugs
- Vol. 6 (2) , 311-316
- https://doi.org/10.1097/00001813-199504000-00016
Abstract
Analysis of tissue culture supernatants collected from cisplatin (10 μg/ml) and carboplatin (50μg/ml)-treated macrophages show enhanced activity of interleukin-1α and tumor necrosis factor-α. Cytotoxicity of these supernatants was demonstrated using mouse sarcoma-180 cells. These results demonstrate the ability of cisplatin and carboplatin to enhance the immune system suggestive of yet another mechanism of their action in the regression of tumors.Keywords
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