Clavulanic acid and penicillin treatment of Staphylococcus aureus renal infection in mice
Open Access
- 1 December 1979
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 16 (6) , 798-800
- https://doi.org/10.1128/aac.16.6.798
Abstract
Clavulanic acid, an inhibitor of beta-lactamase, was used together with penicillin to treat infection caused by a penicillinase-producing Staphylococcus aureus. Clavulanic acid + penicillin administered to mice, prophylactically or in treatment of established infection, reduced morbidity, bacterial counts in the kidneys, and/or mortality; these differences were statistically significant when compared with those obtained by using penicillin or clavulanic acid alone.Keywords
This publication has 12 references indexed in Scilit:
- The inhibition of staphylococcal β-lactamase by clavulanic acidBiochemical Journal, 1979
- Effect of Clavulanic Acid on the In Vitro Synergism Between Carbenicillin and Gentamicin Against Serratia marcescensAntimicrobial Agents and Chemotherapy, 1979
- Effect of Clavulanic Acid on the Minimum Inhibitory Concentration of Benzylpenicillin, Ampicillin, Carbenicillin, or Cephalothin Against Clinical Isolates Resistant to Beta-Lactam AntibioticsAntimicrobial Agents and Chemotherapy, 1979
- Clavulanic Acid, a Novel Inhibitor of β-LactamasesAntimicrobial Agents and Chemotherapy, 1978
- BRONCHOPULMONARY INFECTION DUE TO β-LACTAMASE-PRODUCING BRANHAMELLA CATARRHALIS TREATED WITH AMOXYCILLIN/CLAVULANIC-ACIDThe Lancet, 1978
- In vitro study of clavulanic acid in combination with penicillin, amoxycillin, and carbenicillinAntimicrobial Agents and Chemotherapy, 1978
- Emergence of Variant Forms of Staphylococcus aureus after Exposure to Gentamicin and Infectivity of the Variants in Experimental AnimalsThe Journal of Infectious Diseases, 1977
- Clavulanic Acid: a Beta-Lactamase-Inhibiting Beta-Lactam from Streptomyces clavuligerusAntimicrobial Agents and Chemotherapy, 1977
- Mechanism of Synergistic Effects of β-Lactam Antibiotic Combinations on Gram-Negative BacilliAntimicrobial Agents and Chemotherapy, 1973
- Effect of Pencillinase on the Activity of Penicillins: Synergistic Activity of Penicillins against Penicillinase-producing Gram-negative BacilliNature, 1964