Relative bioavailability of the hydrochloride, sulphate and ethyl carbonate salts of quinine.
Open Access
- 1 February 1988
- journal article
- research article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 25 (2) , 261-263
- https://doi.org/10.1111/j.1365-2125.1988.tb03299.x
Abstract
The hydrochloride, sulphate and ethylcarbonate salts of quinine were given in single oral doses (600 mg base equivalent) to nine healthy male subjects according to a cross-over design. No statistically significant differences were noted in the plasma drug concentration- time profiles although inter- and intra-subject variation in AUC, Cmax and tmax values was appreciable. The ethylcarbonate salt may be preferred for use in paediatric patients because of its neutral taste.This publication has 1 reference indexed in Scilit: