Capillary Shunts in the Pathogenesis of Diabetic Retinopathy

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Abstract
Diabetic retinopathy appears to result from alteration in capillary hemodynamics. We postulate that the specific loss of mural cells from diabetic capillaries removes the tonic control which normally regulates blood flow in the capillaries of the retina. The result is both a diffuse and a microaneurysmal distension of some capillaries with consequent bypassing and ischemia of the adjacent capillaries. Other manifestations of diabetic retinopathy are believed to be secondary to this rerouting of blood flow.

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