Abstract
Inhibition of cholinesterase activity by organophosphates has generally been regarded as the most important primary lesion leading to the death of the intoxicated insects (O'Brien 1960). However, Oppenoorth (1958) observed no difference in the in vitro inhibition of brain cholinesterase activity of susceptible and resistant house flies, Musca domestica L. The present studies show correlation between the in vivo cholinesterase activity in the head of malathion-poisoned German cockroaches, Blatella germanica (L.), and the resistance to the insecticide.

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