Inhibition of Human Tumor Cell Induced Platelet Aggregation by Antibodies to Platelet Glycoproteins lb and llb/llla
- 1 December 1987
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 186 (3) , 378-383
- https://doi.org/10.3181/00379727-186-3-rc1
Abstract
Tumor cell induced platelet aggregation was shown to be inhibited in a dose dependent manner by preincubation of human platelets with antibodies to platelet glycoprotein Ib and the IIb/IIIa complex. Combination of antibody to Ib and antibody to the IIb/IIIa complex at concentrations which produced half maximal inhibition of platelet aggregation alone caused complete inhibition of tumor cell induced platelet aggregation. Antibodies to platelet glycoproteins Ib and the IIb/IIIa complex also inhibited platelet synthesis of thromboxane A2, but not synthesis of 12-hdyroxyeicosatrienoic acid. Inhibition of tumor cell induced platelet aggregation with antibodies against platelet glycoproteins suggests a role for these glycoproteins in tumor cell-platelet interactions and pssibly platelet facilitated tumor cell metastasias.This publication has 11 references indexed in Scilit:
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