Diminished Milk Synthesis in Upstream Stimulatory Factor 2 Null Mice Is Associated With Decreased Circulating Oxytocin and Decreased Mammary Gland Expression of Eukaryotic Initiation Factors 4E and 4G
- 1 November 2003
- journal article
- Published by The Endocrine Society in Molecular Endocrinology
- Vol. 17 (11) , 2251-2267
- https://doi.org/10.1210/me.2002-0031
Abstract
Previous studies have suggested that upstream stimulatory factors (USFs) regulate genes involved with cell cycle progression. Because of the rela- tionship of USFs to an important oncogene in breast cancer, c-myc, we chose to determine the importance of USF to normal mammary gland de- velopment in the mouse. Expression of USF in the mammary gland throughout development demon- strated only modest changes. Mutation of the Usf2 gene was associated with reduced fertility in fe- males, but had no effect on prepartum mammary gland development. However, lactation perfor- mance in Usf2/ females was only half of that observed in Usf2/ females, and both lactose and nitrogen were decreased in milk from Usf2/Keywords
This publication has 71 references indexed in Scilit:
- The Myc/Max/Mad Network and the Transcriptional Control of Cell BehaviorAnnual Review of Cell and Developmental Biology, 2000
- Cloning of an Inr- and E-box-binding protein, TFII-I, that interacts physically and functionally with USF1The EMBO Journal, 1997
- Base preferences for DNA binding by the bHLH-Zip protein USF: effects of MgCl2on specificity and comparison with binding of Myc family membersNucleic Acids Research, 1994
- Ubiquitous expression of the 43- and 44-kDa forms of transcription factor USF in mammalian cellsNucleic Acids Research, 1994
- Direct role for Myc in transcription initiation mediated by interactions with TFII-INature, 1993
- Mad: A heterodimeric partner for Max that antagonizes Myc transcriptional activityCell, 1993
- Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with MycScience, 1991
- Sequence-Specific DNA Binding by the c-Myc ProteinScience, 1990
- The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer.Genes & Development, 1990
- Interaction of a gene-specific transcription factor with the adenovirus major late promoter upstream of the TATA box regionCell, 1985