Effect of Calcium on Parathyroid Secretion1

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Abstract
Measurement of parathyroid secretion has required elaborate perfusions, indirect assays of parathyroid function, or in vitro measurements. This report describes the effect of calcium on the parathyroid using a simple in vivo perfusion. Parathyroids transplanted to the anterior chambers of the eyes of parathyroidectomized rats were perfused with high and low Ca solutions. High Ca perfusion depressed the serum Ca and low Ca perfusion raised the serum Ca, indicating a direct control of the parathyroid by Ca++. During the time of these perfusions, no evidence for the parathyroid or gin of calcitonin could be obtained. The rise in serum Ca was small with low Ca solution due to the relatively small stores of parathyroid hormone during the short term of the experiment.