Effect of Ethionine on Blood and Depot Lipids in Experimental Nephrotic Hyperlipemia.

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Abstract
The nephrotic syndrome was induced in rats of the Sprague-Dawley strain by the intravenous injection of nephrotoxic sera obtained from rabbits. dl-Ethionine reduces the markedly increased plasma lipid concentration of nephrotic rats to normal or subnormal values within 3-5 days. The diminished liver fat values regularly noted in nephrotic rats increased to normal levels under ethionine administration while carcass fat values remain unchanged. The effect of ethionine on hyperlipemia and liver fat of nephrotic rats was noted in female as well as male rats, and was not prevented by methionine. These results lend support to the view that the nephrotic hyperlipemia may be due to an inability of the liver to take up plasma lipids normally.