5' NUCLEOTIDASE ACTIVITY IN LEUKEMIC LYMPHOCYTES

  • 1 January 1976
    • journal article
    • research article
    • Vol. 25  (10) , 363-365
Abstract
The enzyme 5'' nucleotidase (EC 3.1.3.5) is present in lymphocytes isolated from the blood of normal subjects. The activity was extremely low in lymphocytes from 17 patients with B [bone marrow-derived] cell lymphocytic leukemias. Removal of normal lymphocytes from the B-cell leukemic samples further decreased the enzyme activity. Moderately low values were observed in 3 cases of T [thymus-derived] cell-ALL [acute lymphocyte leukemia] and in the cells from a case of Sezary syndrome. Normal or high values were observed in 3 cases of ALL in which T and B cell markers were not demonstrable and in 2 cases of T cell-CLL [chronic lymphocytic leukemia]. No differences were observed in partially purified subpopulations of normal B and T cells.

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