EFFECTS OF OLEIC-ACID, TOLBUTAMIDE, AND OXYPHENBUTAZONE ON THE BINDING OF WARFARIN BY HUMAN-SERUM ALBUMIN

  • 1 January 1979
    • journal article
    • research article
    • Vol. 25  (3) , 577-584
Abstract
Various sorts of drug interactions involving anticoagulants are known to occur. Equilibrium dialysis studies apparently showed that, at low levels, stearate, palmitate and oleate enhanced the binding of warfarin by human serum albumin, but at high levels of FFA [free fatty acids], warfarin was displaced. Tolbutamide and oxyphenbutazone separately displaced warfarin, and this displacement was reduced by the presence of low concentrations of oleate while at higher concentrations of oleate displacement occurred. The binding of warfarin was affected in a complex fashion depending upon the drugs present and the FFA concentration.