Immunogenetics of the rare HLA‐B allele B*4408†
- 19 March 2003
- journal article
- research article
- Published by Wiley in European Journal of Immunogenetics
- Vol. 30 (2) , 129-131
- https://doi.org/10.1046/j.1365-2370.2003.00372.x
Abstract
The nucleotide sequence of exons 2 and 3 of B*4408 has been confirmed. This allele has now been found in five, apparently unrelated, north‐western European Caucasoid subjects, residing in Wales, on HLA haplotypes bearing: A*0201, Cw*0501 with DRB1*0401, DQA1*03, DQB1*0301 in four instances and DRB1*0701, DQA1*0201, DQB1*0202 in one instance. The unique serological reactivity of ‘HLA‐B44BO’ was established using up to nine B*4408 subjects and was easily identified using a variety of B44 and B62 antisera. The phenotype and gene frequencies of B*4408, in a sample of 40 473 subjects residing in Wales, were 0.01235% and 0.00006, respectively.Keywords
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