MAPPING OF GENETIC-CONTROL OF MURINE RESPONSE TO LOW-DOSES OF DINITROPHENYL CONJUGATES OF OVOMUCOID AND BOVINE GAMMA-GLOBULIN

  • 1 January 1976
    • journal article
    • research article
    • Vol. 117  (5) , 1514-1518
Abstract
The antibody responses in mice to low doses of the DNP[dinitrophenyl]-conjugates of ovomucoid (OM) and bovine .gamma.-globulin (BGG) were measured for a number of inbred strains carrying independent and recombinant H-2 haplotypes. This permitted mapping the gene(s) controlling the response to low doses of OM (Ir-l-OM) within the I-A subregion of the H-2 complex. It was possible to map the primary gene(s) controlling the response to low doses of BGG (Ir-l-BGG) within the I-A and/or I-B subregions. Further localization of the Ir-l-BGG gene(s) to the I-A or I-B subregion of the H-2 complex was not possible due to the ambiguous response of the B10.A(4R) strain of mice.

This publication has 1 reference indexed in Scilit: