Close linkage between the C blood group locus and the locus controlling amino acid transport in sheep erythrocytes

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Abstract
Data from 838 Finnish Landrace or Finnish Landrace crossbred sheep showed a highly significant correlation between phenotypes of the C blood group system and erythrocyte amino acid transport variants. Erythrocytes with normal amino acid transport properties (GSH [glutathione] high, Ly[lysine]- type) were Cb-positive or Cb-negative. Erythrocytes with the amino acid transport lesion (GSH low, Ly+) were never Cb-negative. Sheep erythrocytes homozygous for Cb showed stronger lysis reactions with anti-Cb than heterozygous cells. Ly+ sheep were nearly always homozygous for Cb, whereas most Ly- sheep were heterozygous or Cb-negative. Inheritance studies provided strong evidence that this association is due to close genetic linkage.