Synthesis and structure-activity relations of 5H,11H-[2]benzopyrano[4,3-g][1]benzopyran-9-carboxylic acids
- 1 February 1977
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 20 (2) , 205-209
- https://doi.org/10.1021/jm00212a004
Abstract
The synthesis and properties of the title compounds 1 are described. Many of these compounds are potent inhibitors of the passive cutaneous anaphylaxis reaction of rats against egg albumin challenge. Structural variations include substitutions in the 2, 3, 4, 5, 7 and 12 position of the nucleus 1. A novel rearrangement from a compound of the related [3,4-f] series to this group is reported.This publication has 0 references indexed in Scilit: