Rifampicin-resistant bacteriophage PBS2 Infection and RNA polymerase in Bacillus subtills
Open Access
- 1 January 1974
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 1 (11) , 1497-1502
- https://doi.org/10.1093/nar/1.11.1497
Abstract
Bacteriophage PBS2 replication is unaffected by rifampicin and other rifamycin derivatives, which are potent inhibitors of Bacillus subtilis RNA synthesis. Extracts of gently-lysed infected cells contain a DNA-dependent RNA polymerase activity which is specific for uracil-containing PBS2 DNA. The PBS2-induced RNA polymerase is insensitive to rifamycin derivatives which inhibit the host's RNA polymerase.Keywords
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