Suppression of the Foreign Bone Marrow Reaction by Preirradiation of Donor Mice

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Abstract
Preirradiation of donor mice with 400–500 r of X-rays resulted in a marked reduction of secondary disease in homologous radiation bone marrow chimeras. The results are tentatively attributed to elimination of immunologically competent cells from donor marrow by X radiation to an extent adequate to inhibit the development of clinically significant graft-versus-host immune reactions. This effect was not detectably inhibited by administration of a radioprotective compound (AET) 20–30 minutes before irradiation of donor mice, implying that AET did not protect immunologically competent cells to the same extent as hemopoietic cells against radiation injury.