Active suppression of 1-fluoro-2,4-dinitrobenzene-immune T cells. Requirement of an auxiliary T cell induced by antigen.

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Abstract
T[thymus-derived]-T cell interactions in the suppression of contact sensitivity were investigated. Suppressor cells that block the efferent limb of sensitivity (Ts-eff) inhibited the passive transfer of contact sensitivity mediated by 1-fluoro-2,4-dinitrobenzene immune cells (TDH). Ts-eff could not block the passive transfer of TDH which comes from cyclophosphamide (Cy) pretreated sensitized mice. Lymph node cells from sensitized mice apparently contained TDH and another intermediate cell which is required for the suppression of TDH by Ts-eff. This intermediate cell was sensitive to cyclophosphamide and required antigen activation for its development. It was sensitive to adult thymectomy and anti-brain associated .theta. serum and was designated as an auxiliary T-suppressor cell (Ts-aux). It was not sensitive to splenectomy, and it carried I-J determinants. Ts-aux were required for the activity of suppressors of the efferent limb (Ts-eff) but not of suppressors of the afferent limb (Ts-aff). In the feedback loops in contact sensitivity, the generation of TDH was coordinated with the development of auxillary Ts which were essential for the suppression of those TDH.