EXPERIMENTAL AND CLINICAL PHARMACOKINETICS OF NITROFURANTOIN IN THE EARLY PERIOD OF LIFE

  • 1 January 1982
    • journal article
    • research article
    • Vol. 17  (2) , 293-299
Abstract
The investigations of pharmacokinetics showed an age-dependent rate of nitrofurantoin elimination in rats. Nitrofurantoin half-life of 0.41 h in adults was prolonged to 0.95 h in 2-wk-old rats. Nitrofurantoin excretion rate was decreased in children < 2 yr old. Older children excreted in urine 44.32 .+-. 16.07 and younger 25.07 .+-. 5.7% of the given dose of nitrofurantoin, indicating the lower capacity for nitrofurantoin elimination via kidneys.

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