Treatment of Classic Hemophilia: The Use of Fibrinogen Rich in Factor VIII for Hemorrhage and for Surgery

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Abstract
Effects of Fraction I in Surgical Intervention (Cases 8–15)As applied to the supportive management of patients with classic hemophilia undergoing various emergency and elective surgical procedures, fraction I therapy was associated with a spectrum of effects. Fraction I therapy instituted before and adequately maintained after operation. In 2 cases of appendectomy (Cases 8 and 9) and 2 of dental extractions (Cases 10a and 11), the exclusive use of fraction I for replacement therapy supported uneventful operative and postoperative phases. These surgical procedures progressed within clearly normal limits with 1 exception (Case 11), in which elective extraction of an abscessed . . .