The Rh-negative donor

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Abstract
Summary By typing fully for Rh, donor samples found to be D‐negative but C‐positive and/or E‐positive on the Kontron Groupamatic G2000, the incidence of ccddee (r′r) was found to be 0.44%, ccddEe (r″r) 0.50% and Du 0.30%. A total of 15 000 samples typed on the Groupamatic as D‐, C‐ and E‐negative were tested by an antiglobulin technique for Du, but none was found to be positive. A new strategy was therefore adopted for routine Rh typing of donations that includes typing first‐time donors on the Groupamatic for C, D and E antigens; those that type as D‐negative, C‐positive and/or E‐positive are further tested but no routine Du testing of D‐, C‐ and E‐negative donations is performed. Donations are labelled according to their D type, and the once used terminology ‘Rh‐positive donor, Rh‐negative recipient’ is no longer used except for those rare Rh D‐positive donors belonging to the D category VI of Tippett & Sanger (1962).

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