CHROMOGENIC ACID-FAST BACILLI - THEIR USE IN VACCINATION AGAINST TUBERCULOSIS IN THE GUINEA PIG
- 1 January 1948
- journal article
- research article
- Published by Elsevier
- Vol. 57 (4) , 385-388
- https://doi.org/10.1164/art.1948.57.4.385
Abstract
75 guinea pigs were vaccinated with chromogenic acid-fast bacilli frequently seen on the culture media at the sanatorium. After vaccination, the guinea pigs became hypersensitive to tuberculin. After infecting these vaccinated animals with various doses of a virulent strain of human-type tubercle bacilli, a definite, but not complete, immunity was produced. Vaccinated guinea pigs receiving a massive infecting dose developed more tuberculosis than did the controls receiving the same dose.Keywords
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