New Antimalarial Bis-dehydroaporphine Alkaloids from Polyalthia debilis
- 18 April 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 66 (5) , 616-619
- https://doi.org/10.1021/np020498d
Abstract
Four new dimeric aporphinoids named bidebilines A−D (1−4), bis-7,7‘-dehydroanonaine (1), 7-dehydroanonaine-7‘-dehydro-8‘-methoxyanonaine (2), bis-7,7‘-dehydro-8,8‘-dimethoxyanonaine (3), and bis-7,7‘-dehydro-10,10‘-dimethoxyanonaine (4), were isolated from the roots of Polyalthia debilis. Their structures were established on the basis of spectral evidence. Compounds 3 and 4 exhibited moderate antimalarial activity with IC50 values of 5.4 and 4.1 μg/mL, respectively.Keywords
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