Species Dependence for Binding of Small Molecule Agonist and Antagonists to the C5a Receptor on Polymorphonuclear Leukocytes
- 1 January 2001
- journal article
- research article
- Published by Springer Nature in Inflammation
- Vol. 25 (3) , 171-177
- https://doi.org/10.1023/a:1011036414353
Abstract
This study investigated the receptor binding affinities of a C5a agonist and cyclic antagonists for polymorphonuclear leukocytes (PMNs) isolated from human, sheep, pig, dog, rabbit, guinea pig, rat...Keywords
This publication has 29 references indexed in Scilit:
- Pharmacological characterization of antagonists of the C5a receptorBritish Journal of Pharmacology, 1999
- Effects of a new C5a receptor antagonist on C5a- and endotoxin- induced neutropenia in the ratBritish Journal of Pharmacology, 1999
- Cloning and characterization of the guinea pig C5a anaphylatoxin receptor: interspecies diversity among the C5a receptors.International Immunology, 1998
- Expression of the receptor for complement C5a (CD88) is up-regulated on reactive astrocytes, microglia, and endothelial cells in the inflamed human central nervous system.1997
- Anti-C5 monoclonal antibody therapy prevents collagen-induced arthritis and ameliorates established disease.Proceedings of the National Academy of Sciences, 1995
- Arginine 206 of the C5a Receptor Is Critical for Ligand Recognition and Receptor Activation by C-terminal Hexapeptide AnalogsPublished by Elsevier ,1995
- Two-site binding of C5a by its receptor: analternative binding paradigm for G protein-coupled receptors.Proceedings of the National Academy of Sciences, 1994
- Structural diversity in the extracellular faces of peptidergic G-protein-coupled receptors. Molecular cloning of the mouse C5a anaphylatoxin receptor.The Journal of Immunology, 1992
- ENDOTOXIN-INDUCED SHOCK IN THE RAT - A ROLE FOR C5A1989
- Effects of anti-C5a antibodies on the adult respiratory distress syndrome in septic primates.Journal of Clinical Investigation, 1986