Effect of adenosine‐induced controlled hypotension on canine myocardial performance, blood flow and metabolism

Publisher Website
Google Scholar
Abstract
The effect of adenosine‐induced controlled hypotension (CH) on myocardial performance, blood flow, and metabolism was studied in nine pentobarbital‐anaesthetized, open‐chest dogs. Adenosine was continuously infused i. v. (0.69 0.06 and 1.36 0.11 mg/kg/min) at two stepwise increased rates (12–14 min‐periods) in order to induce approximately 20 and 40% reduction of the mean arterial pressure (MAP 62 4 and 43 1 mmHg, respectively). The reduction of MAP was associated with decreases in heart rate (6 2%,PPPPPPPPPPPP<0.01) during the highest infusion rate. The myocardial lactate uptake and the left ventricular subendocardial ECG (n = 4) were unchanged during CH. In conclusion, adenosine‐induced CH in the canine open‐chest preparation reduced myocardial work as well as oxygen uptake, and increased the total myocardial blood flow. No signs of regional myocardial ischaemia appeared, as judged from the unaffected myocardial lactate uptake and left ventricular sub‐endocardial ECG.