Acid-Free Aza Diels−Alder Reaction of Danishefsky's Diene with Imines
- 29 August 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 4 (19) , 3309-3311
- https://doi.org/10.1021/ol0265822
Abstract
A highly efficient aza Diels−Alder reaction of Danishefsky's diene with imines was found to occur in methanol in the absence of any acids at room temperature to give corresponding 2-substituted dihydro-4-pyridone derivatives in high yields. This reaction can be also carried out in a three-component one-pot reaction manner. The reaction was found to proceed through a Mannich-type condensation mechanism.Keywords
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