PLATELET AGGREGATING MATERIAL IN MOUSE TUMOR-CELLS - REMOVAL AND REGENERATION

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 36  (4) , 413-419
Abstract
The platelet aggregating principle of 2 mouse ascites tumors and their cell free supernatants released spontaneously was studied. The principle disappeared from the cells after trypsin digestion and part of it was recovered in the cell free trypsinate. Digested cells regenerated the principle during subsequent incubation by a process requiring protein synthesis. The principle was spontaneously released by intact cells into the medium and sensitive to proteolytic attack. The principle was not present in 5 varieties of nonneoplastic cells. Since previous work indicates that the principle is present in numerous other tumor cell lines, its study might reveal it to be an indicator of malignant transformation or malignant progression.