STUDIES ON TERMINAL STAGES OF ANTIBODY-COMPLEMENT-MEDIATED KILLING OF A TUMOR-CELL .2. INHIBITION OF TRANSFORMATION OF T-STAR TO DEAD CELLS BY 3'5' CAMP
- 1 January 1976
- journal article
- research article
- Vol. 116 (5) , 1276-1279
Abstract
Transformation of T* [line-1 guinea pig hepatoma cells] to dead cells was prevented by c[cyclic]AMP. The effect of cAMP was dose, time and temperature dependent. T* washed free of cAMP after short-term incubation, proceeded to die to the same extent as control cells. After 3 h of incubation of T* with cAMP, the level of killing was significantly reduced. The 3''5'' cyclic nucleotides of uridine, guanine, cytosine and thymidine and the 2''3'' cyclic adenosine nucleotide were not effective. Prolonged treatment of T* with cAMP irreversibly blocked the damage-producing process or facilitated the repair of damaged sites.This publication has 4 references indexed in Scilit:
- STUDIES ON TERMINAL STAGES OF ANTIBODY-COMPLEMENT-MEDIATED KILLING OF A TUMOR-CELL .1. EVIDENCE FOR EXISTENCE OF AN INTERMEDIATE, T1976
- STUDIES ON TERMINAL STEPS OF IMMUNE HEMOLYSIS .2. RESOLUTION OF E] TRANSFORMATION REACTION INTO MULTIPLE STEPS1965
- STUDIES ON TERMINAL STEPS OF IMMUNE HEMOLYSIS .I. INHIBITION BY TRISODIUM ETHYLENEDIAMINETETRAACETATE ( EDTA )1964
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