Viral and cellular messenger RNA targets of viral microRNAs
Top Cited Papers
- 21 January 2009
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 457 (7228) , 421-425
- https://doi.org/10.1038/nature07757
Abstract
Given the propensity of viruses to co-opt cellular pathways and activities for their benefit, it is perhaps not surprising that several viruses have now been shown to reshape the cellular environment by reprogramming the host's RNA-interference machinery. In particular, microRNAs are produced by the various members of the herpesvirus family during both the latent stage of the viral life cycle and the lytic (or productive) stage. Emerging data suggest that viral microRNAs are particularly important for regulating the transition from latent to lytic replication and for attenuating antiviral immune responses.Keywords
This publication has 40 references indexed in Scilit:
- Evolutionarily Conserved Function of a Viral MicroRNAJournal of Virology, 2008
- An Epstein-Barr virus–encoded microRNA targets PUMA to promote host cell survivalThe Journal of Experimental Medicine, 2008
- A combined computational and microarray-based approach identifies novel microRNAs encoded by human gamma-herpesvirusesRNA, 2006
- Identification and Characterization of Human Cytomegalovirus-Encoded MicroRNAsJournal of Virology, 2005
- SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cellsNature, 2005
- Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cellsProceedings of the National Academy of Sciences, 2005
- Identification of microRNAs of the herpesvirus familyNature Methods, 2005
- Identification of Virus-Encoded MicroRNAsScience, 2004
- MicroRNAsCell, 2004
- The γ 1 34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1α to dephosphorylate the α subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinaseProceedings of the National Academy of Sciences, 1997