A new class of proteins regulating gene expression in enterobacteria
- 1 January 1994
- journal article
- Published by Wiley in Molecular Microbiology
- Vol. 11 (1) , 77-86
- https://doi.org/10.1111/j.1365-2958.1994.tb00291.x
Abstract
YmoA and Hha are highly similar bacterial proteins downregulating gene expression In Yersinia entero-colitlca and Escherichia coli. respectively. The pheno-type of ymoA mutants evokes that of mutants affected in some histone-like proteins. This paper describes complementation of a ymoA mutation in Y. enterocolitica by the hha gene from E. coli. We show that YmoA and Hha are not only very similar proteins but that they are functionally Interchangeable. Genetic experiments indicate that Hha can also stimulate transposition events in vivo. By Southern Biol analysis we detected hha-homologous genes at least in Citrobacter diversus, Shigella flexneri, Shigella dysenteriae, Klebsiella pneumoniae and Salmonella typhimurium. We suggest that both YmoA and Hha belong to a new family of proteins down regulating gene expression in different enterobacteria.Keywords
This publication has 35 references indexed in Scilit:
- DNA topology and bacterial virulence gene regulationTrends in Microbiology, 1993
- Synthesis of the Escherichia coli K‐12 nucleoid‐associated DNA‐binding protein H‐NS is subjected to growth‐phase control and autoregulationMolecular Microbiology, 1993
- Overproduction of aClostridium cellulolyticumendoglucanase by mutant strains ofEscherichia coliFEMS Microbiology Letters, 1991
- Protein H1: a role for chromatin structure in the regulation of bacterial gene expression and virulence?Molecular Microbiology, 1990
- A physiological role for DNA supercoiling in the osmotic regulation of gene expression in S. typhimurium and E. coliCell, 1988
- Secretion of anAeromonas hydrophilaaerolysin by a mutant strain ofEscherichia coliFEMS Microbiology Letters, 1987
- Transcription of the yop regulon from Y. enterocolitica requires trans acting pYV and chromosomal genesMicrobial Pathogenesis, 1987
- Functional promoters created by the insertion of transposable element IS1Journal of Molecular Biology, 1986
- A Broad Host Range Mobilization System for In Vivo Genetic Engineering: Transposon Mutagenesis in Gram Negative BacteriaBio/Technology, 1983
- Restriction of DNA in Yersinia enterocolitica Detected Recipient Ability for a Derepressed R Factor from Escherichia coliJournal of General Microbiology, 1975