THE EFFECT OF INTRAVITREAL AND TOPICAL PROSTAGLANDINS ON INTRAOCULAR INFLAMMATION

  • 1 January 1982
    • journal article
    • research article
    • Vol. 23  (3) , 383-392
Abstract
The effects were studied of prostaglandins (PG) E2, PGD2, PGI2, and its metabolites 6-keto-PGE1 and 6-keto-PGF1.alpha., and U46619 [15S-hydroxy-11-.alpha.-9-.alpha.-(epoxymethano)-prosta-5Z,13E-dienoic acid] (stable analog of the PGE endoperoxide, PGH2) administered either intravitreally or topically on intraocular pressure (IOP), pupil diameter, aqueous protein and the entry of polymorphonuclear celLS (PMN) in the aqueous. PGE2, 6-keto-PGE1, U46619 and PGI2 increased IOP after either intravitreal or topical admimnistration in a dose-dependent manner; 6-keto-PGE1 was the most potent in increasing IOP. U46619 and PGI2 increased IOP when administered intravitreally. These agents also increased IOP of the contralateral control eye. High doses of 6-keto-PGE1 and PGI2, but not 6-keto-PGF1.alpha. or PGE2, increased the IOP of both experimental and contralateral eyes, suggesting that this effect may be due to the entry of these agents into the systemic or intraorbital circulation or to stimulation of neuronal pathways. Intravitreal administration of 6-keto-PGE1, PGE2, and PGI2 increased protein content of the aqueous, with 6-keto-PGE1 being significantly more potent than other PG. Topically applied PGE2 and 6-keto-PGE1 also increased protein content of the aqueous at doses that elevated IOP. Topical 6-keto-PGE1.alpha. at doses that increased IOP did not increase protein content of the aqueous. PGD2 increased the IOP in both eyes and significantly increased aqueous protein content of the experimental eye, indicating that increase in protein content of the aqueous and increase in IOP are not necessarily associated. None of the PG tested had any effect on pupil diameter or PMN entry into the aqueous. Evidently, the classic signs of intraocular inflammation, i.e., increase in IOP, increase in protein content of the aqueous, miosis and PMN entry into aqueous, are not necessarily associated and sequential, and PG do not induce all signs of inflammation.