Actin filaments of hepatocytes in experimental rat cholestasis - Observations using a fluorescent staining method by DACM labeled heavy meromyosin.

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Abstract
Actin filaments of hepatocytes in 3 types of experimental rat cholestasis were examined by a previously reported method. Liver treated with cytochalasin B in vivo showed bile canalicular dilation and the obscure polygonal pattern of heaptocytes depended upon partial loss and granular aggregation in peripheral fluorescence. Liver treated with phalloidin showed an accumulation of fluorescence mainly around bile canaliculi in addition to an accumulation in the cytoplasms and nucleus in hepatocytes. Liver ligated with common bile duct showed increased fluorescence in the peripheral cytoplasms of hepatocytes, particularly around bile canaliculi, but this alteration varied according to the duration of ligation.