Strain-Dependent Differences in the Specificity of Antibody Responses toward Lysozyme

Abstract
Summary: Most mouse strains responded well to immunization with lysozyme, but only certain strains produced antibodies against a conjugate consisting of the “loop” region (residues 60–83) of lysozyme attached to a synthetic polymer. The latter strains, which did not respond to the above synthetic conjugate, were also unable to produce antibodies specific for the “loop” region when injected with intact lysozyme. The F1 hybrid between low and high responders showed an intermediate response. It appears that the immune response to the natural determinants of proteins is genetically controlled.

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