MicroRNA function: Multiple mechanisms for a tiny RNA?: FIGURE 1.
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Open Access
- 28 November 2005
- journal article
- review article
- Published by Cold Spring Harbor Laboratory in RNA
- Vol. 11 (12) , 1753-1761
- https://doi.org/10.1261/rna.2248605
Abstract
MicroRNAs are sequence-specific regulators of post-transcriptional gene expression in many eukaryotes. They are believed to control the expression of thousands of target mRNAs, with each mRNA believed to be targeted by multiple microRNAs. Recent studies have uncovered various mechanisms by which microRNAs down-regulate their target mRNAs and have linked a well-known subcellular structure, the cytoplasmic processing bodies (PBs) to the microRNA pathway. The finding that microRNAs are misexpressed in cancers has reinforced the idea that their regulatory roles are very important.Keywords
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