Double-blind controlled trial of sertraline versus paroxetine in the treatment of delusional depression

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Abstract
In this study the authors evaluated the efficacy and the tolerability of sertraline and paroxetine in the treatment of delusional depression. Under double-blind conditions, 46 hospitalized patients who met the DSM-III-R criteria for major depression with psychotic features were treated with sertraline or paroxetine for 6 weeks. The response rates were 75% and 46% for sertraline and paroxetine, respectively. The dropout rate was substantial (41%) in the paroxetine group and was attributable to side effects. Selective serotonin reuptake inhibitors administered alone are useful in the treatment of delusional depression.

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