Sensitivity of Human and Murine Hemopoietic Precursor Cells to Chemotherapeutic Agents Assessed in Cell Culture

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Abstract
The sensitivity of human and murine hemopoietic precursor cells to 1,3 bis (2 chloroethyl)-1-nitrosourea (BCNU), nitrogen mustard, 5-fluorouracil, and melphalan was assessed in culture using colony assay techniques. The results indicate that human and murine hemopoietic cells may differ in their intrinsic sensitivity to drugs. The hematologic toxicity of some chemotherapeutic agents cannot be extrapolated directly from mouse to man.