Cancer therapy: switching off oncogenes
- 1 February 2003
- Vol. 25 (2) , 104-107
- https://doi.org/10.1002/bies.10238
Abstract
Cancer derives from a cell clone that has accumulated genetic and epigenetic changes that influence its phenotype and finally enable it to escape from the normal controls of proliferation. A recent paper shows that, in myc‐induced tumours, the inactivation of this oncogene produces the regression of the tumours and the differentiation of the tumour cells into mature osteocytes.1 In addition, a further reactivation of myc in these cells does not restore the malignant phenotype but induces apoptosis. This discovery could lead to an innovative therapeutic strategy. BioEssays 25:104–107, 2003.Keywords
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