Casein kinase 1 delta (CK1δ) interacts with the SNARE associated protein snapin
- 7 November 2006
- journal article
- Published by Wiley in FEBS Letters
- Vol. 580 (27) , 6477-6484
- https://doi.org/10.1016/j.febslet.2006.10.068
Abstract
In this study we identified snapin as an interaction partner of the CK1 isoform delta (CK1δ) in the yeast two-hybrid system and localized the interacting domains of both proteins. The interaction of CK1δ with snapin was confirmed by co-immunoprecipitation. Snapin was phosphorylated by CK1δ in vitro. Both proteins localized in close proximity in the perinuclear region, wherein snapin was found to associate with membranes of the Golgi apparatus. The identification of snapin as a new substrate of CK1δ points towards a possible function for CK1δ in modulating snapin specific functionsKeywords
This publication has 30 references indexed in Scilit:
- Casein kinase Iε associates with and phosphorylates the tight junction protein occludinFEBS Letters, 2006
- CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signalingGenes & Development, 2006
- Effects of PKA-Mediated Phosphorylation of Snapin on Synaptic Transmission in Cultured Hippocampal NeuronsJournal of Neuroscience, 2004
- Identification and characterization of Snapin as a ubiquitously expressed SNARE-binding protein that interacts with SNAP23 in non-neuronal cellsBiochemical Journal, 2003
- Centrosomal Anchoring of the Protein Kinase CK1δ Mediated by Attachment to the Large, Coiled-coil Scaffolding Protein CG-NAP/AKAP450Journal of Molecular Biology, 2002
- Phosphorylation of Synaptic Vesicle Protein 2 Modulates Binding to SynaptotagminJournal of Biological Chemistry, 2000
- Nerve Growth Factor‐Induced Phosphorylation of SNAP‐25 in PC12 CellsJournal of Neurochemistry, 2000
- Phosphorylation of 25-kDa Synaptosome-associated ProteinPublished by Elsevier ,1996
- Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane trafficCell, 1991
- A synthetic peptide substrate specific for casein kinase‐1FEBS Letters, 1989