Abstract
Summary Almost one century after Galton's first scientific formulation of the Twin Method, based on the comparison of MZ and DZ twin series, not only twin studies play a fundamental role and the Interzygotic Test is widely applied in human and especially medical genetic research, but new methods have also been worked out, such as the Azygotic Test and the Twin Clinical Method. Moreover, the study of twins has more recently led to new insights into the study of biological times, with the development of the modern branch of Chronogenetics.

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