FORMATION OF OSTEOCLASTS FROM BLOOD MONOCYTES DURING 1-ALPHA-OH VIT-D-STIMULATED BONE-RESORPTION IN MICE
- 1 January 1981
- journal article
- research article
- Vol. 133 (OCT) , 389-396
Abstract
To investigate a monocyte origin for osteoclasts, 3H-thymidine labeled blood monocytes, harvested from the blood of donor mice, were injected i.v. into syngeneic recipient animals in which osteoclast formation was being stimulated by concomitant i.p. injections of 1 .alpha.-hydroxycholecalciferol. Labeled osteoclasts were found in autoradiographs prepared from the femurs of recipient mice, demonstrating for the 1st time that, during hormonally stimulated osteoclast formation, blood monocytes form 1 source of osteoclasts.This publication has 20 references indexed in Scilit:
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